Molecules that serve similar functions for different organisms

Integrated Analysis of miRNAs and DNA Methylation identifies miR-132-3p as a Tumor suppressor

Integrated Analysis of miRNAs and DNA Methylation identifies miR-132-3p as a Tumor suppressor

Built-in evaluation of miRNAs and DNA methylation identifies miR-132-3p as a tumor suppressor in lung adenocarcinoma

Background: Aberrant miRNA expression and DNA methylation are two main epigenetic occasions in lung adenocarcinoma (LUAD). We carried out a mixed evaluation of the molecular adjustments in LUAD.
Strategies: We analyzed differentially expressed miRNAs and methylated CpG loci in 489 LUAD tissues versus 49 regular lung tissues of the Most cancers Genome Atlas (TCGA). The outcomes had been validated in cell traces and xenograft mouse fashions and extra pairs of 36 LUAD and 36 regular lung tissues.
Outcomes: A complete of 125 differentially expressed miRNAs and 145 differentially methylated CpG loci had been recognized within the LUAD versus regular lung tissues of TCGA information. Expression of the 22 miRNAs was inversely correlated with the 47 differentially methylated websites situated within the miRNAs.
Molecular and mobile perform evaluation confirmed that the abnormally methylated miRNAs had been primarily concerned in cell-to-cell signaling and interplay in airway cells. The DNA methylation standing and altered expressions of miRNAs and their goal genes had been confirmed in 36 pairs of lung tumor and noncancerous lung tissues. Moreover, aberrant miRNA expressions or DNA methylations alone might be concerned in tumorigenesis of LUAD through completely different pathways.
As well as, elevated miR-132-3p expression, diminished expression of its focused gene (ZEB2), and decreased cell proliferation was noticed in lung most cancers cells handled with DNA methyltransferase inhibitor. Furthermore, in vitro and in vivo analyses confirmed that miR-132-3p-3p downregulation through DNA methylation promoted tumorigenicity of lung most cancers by immediately regulating ZEB2.
Conclusions: The interplay between two epigenetic aberrations might have necessary capabilities in LUAD. miR-132-3p may act as a tumor suppressor within the tumorigenicity of LUAD.
Key factors: SIGNIFICANT FINDINGS OF THE STUDY: Systemically investigating relationship between aberrant miRNA expression and DNA methylation in lung most cancers might enhance understanding of lung tumorigenesis and develop diagnostic and therapeutic targets.
What this research provides: Three types of relationships between the 2 epigenetic adjustments are outlined. miR-132-3p is additional recognized as a tumor suppressor in lung most cancers.
Key phrases: DNA methylation; epigenetics; lung most cancers; microRNA
cdna-clone
cdna-clone

cDNA - Monkey (Rhesus) Normal Tissue: Kidney

C1534142 40 reactions
EUR 385

cDNA - Monkey (Cynomolgus) Normal Tissue: Kidney

C1534142-Cy 40 reactions
EUR 385

Matched Pair - cDNA - Human Primary Tumor and Normal Tissue: Kidney

C8235142-PP 10 reactions x2
EUR 530

Total RNA - Rat Normal Tissue: Kidney

R1434142-50 50 ug
EUR 130

Genomic DNA - Rat Normal Tissue: Kidney

D1434142 100 ug
EUR 286

Rat normal kidney tissue array

TR071a each
EUR 48
Description: Rat normal kidney tissue array, 6 cases/24 cores, replacing TR071

Normal kidney and normal adjacent kidney tissue array

KDN241a each
EUR 138
Description: Normal kidney and normal adjacent kidney tissue array, 24 cases/ 24 cores

Kidney cancer tissue array with normal Kidney tissue

KD2082a each
EUR 474
Description: Kidney cancer tissue array with normal Kidney tissue, including TNM and pathology grade, 96 cases/192 cores, replacing KD2082

Kidney Tissue Slide (Normal)

10-401-10um 10 um
EUR 241.8

Kidney Tissue Slide (Normal)

10-401-4um 4 um
EUR 216.6

Normal kidney tissue array

KD803 each
EUR 354
Description: Normal kidney tissue array, replacing BN07012, 80 cases/80 cores

Normal kidney tissue array

KDN242 each
EUR 72
Description: Normal kidney tissue array, 24 cases/24 cores

Kidney Tissue Lysate (Normal)

1706-02 0.1 mg
EUR 260.7
Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Kidney Tissue Lysate (Normal)

1706-03 0.1 mg
EUR 260.7
Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Kidney Tissue Lysate (Normal)

1706-04 0.1 mg
EUR 260.7
Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Kidney Tissue Lysate (Normal)

1706-05 0.1 mg
EUR 260.7
Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Kidney cancer tissue array with adjacent normal kidney tissue

BC07015b each
EUR 168
Description: Kidney cancer tissue array with adjacent normal kidney tissue, including TNM, clinical stage and pathology grade, 72 cases/72 cores, replacing BC07015a

Total RNA - Mouse Normal Tissue: Kidney

R1334142-50 50 ug
EUR 130

Genomic DNA - Mouse Normal Tissue: Kidney

D1334142 100 ug
EUR 286

Total Protein - Mouse Normal Tissue: Kidney

P1334142 1 mg
EUR 188

Kidney cancer tissue array with matched adjacent normal kidney tissue

KD901a each
EUR 258
Description: Kidney cancer tissue array with matched adjacent normal kidney tissue, including TNM, clinical stage and pathology grade, 40 cases/90 cores, replacing KD901

Kidney tumour with normal tissue array

KD2001 each
EUR 474
Description: Kidney tumour with normal tissue array, including Clear cell carcinoma (CCRCC), Sarcomatoid carcinoma, Papillary renal cell carcinoma (PRCC), Chromopobe carcinoma(crcc), Invasive low grade urothelial carcinoma, with Isup Grade, TNM/Stage (AJCC 8th edition), 100 cases/200 cores (core size 1.0mm),replacing BC07114

Total RNA - Human Adult Normal Tissue: Kidney

R1234142-50 50 ug
EUR 170

cDNA - Rat Normal Tissue: Lung

C1434152 40 reactions
EUR 385

cDNA - Rat Normal Tissue: Brain

C1434035 40 reactions
EUR 385

cDNA - Rat Normal Tissue: Colon

C1434090 40 reactions
EUR 578

cDNA - Rat Normal Tissue: Heart

C1434122 40 reactions
EUR 385

cDNA - Rat Normal Tissue: Liver

C1434149 40 reactions
EUR 385

Kidney cancer tissue array with normal tissues

KD2083 each
EUR 474
Description: Kidney cancer tissue array with normal tissues, with stage and grade info, 69 cases/208 cores

Kidney cancer tissue array with normal tissues

KD721 each
EUR 168
Description: Kidney cancer tissue array with normal tissues, 24 cases/72 cores

cDNA - Rat Normal Tissue: Rectum

C1434206 40 reactions
EUR 578

cDNA - Rat Normal Tissue: Spleen

C1434246 40 reactions
EUR 385

cDNA - Rat Normal Tissue: Testis

C1434260 40 reactions
EUR 385

Mouse Normal Tissue: Kidney Whole Cell Lysate

MNK-100 1 mg
EUR 628.8

Mouse Normal Tissue: Kidney Whole Cell Lysate

MNK-50 50 ug
EUR 196.8

Total RNA - Monkey (Rhesus) Normal Tissue: Kidney

R1534142-50 50 ug
EUR 191

cDNA - Rat Normal Tissue: Adipose

C1434003 40 reactions
EUR 578

cDNA - Rat Normal Tissue: Bladder

C1434010 40 reactions
EUR 385

cDNA - Rat Normal Tissue: Stomach

C1434248 40 reactions
EUR 385

cDNA - Rat Normal Tissue: Placenta

C1434200 40 reactions
EUR 578

Kidney tumor tissue array with normal tissue as control

KD961 each
EUR 258
Description: Kidney tumor tissue array with normal tissue as control, including TNM, clinical stage and pathology grade, 48 cases/96 cores

Total Protein - Human Adult Normal Tissue: Kidney

P1234142 1 mg
EUR 188

Kidney cancer tissue array with normal tissue as control

KD962 each
EUR 258
Description: Kidney cancer tissue array with normal tissue as control, including TNM, clinical stage and pathology grade, 48 cases/96 cores

Rat Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells

9-80263 1 x 100 ml Ask for price

Total RNA - Monkey (Cynomolgus) Normal Tissue: Kidney

R1534142-Cy 50 ug
EUR 191

Membrane Protein - Human Adult Normal Tissue: Kidney

P3234142 0.1 mg
EUR 270

Adjacent normal kidney tissue and cancer tissue array

BN07011b each
EUR 203
Description: Adjacent normal kidney tissue and cancer tissue array, including pathology grade, TNM and clinical stage, 20 cases/54 cores, replacing BN07011

Kidney cancer (grade I) tissue array with matched adjacent normal kidney tissue

KD701a each
EUR 234
Description: Kidney cancer (grade I) tissue array with matched adjacent normal kidney tissue, including TNM, clinical stage and pathology grade, 35 cases/70 cores, replacing KD701

cDNA - Human Tumor Tissue: Kidney

C1235142 40 reactions
EUR 578

Kidney cancer tissue array with matched adjacent normal tissue

KD321a each
EUR 198
Description: Kidney cancer tissue array with matched adjacent normal tissue, including TNM, clinical stage and pathology ISUP grade, 16 cases/32 cores, replacing KD321

Kidney cancer with matched adjacent normal kidney tissue array

KD603 each
EUR 204
Description: Kidney cancer with matched adjacent normal kidney tissue array, containing metastatic clear cell carcinoma, including pathology grade, TNM and clinical stage (reference AJCC 8th version), 33 cases/61 cores

Kidney cancer tissue array with matched normal adjacent or caner adjacent kidney tissue

Kid-060Sur01 each
EUR 954
Description: Kidney cancer tissue array with matched normal adjacent or caner adjacent kidney tissue, including TNM, ISUP grade and survival data, 30 cases/60 cores

cDNA - Rat Normal Tissue: Skeletal Muscle

C1434171 40 reactions
EUR 385

cDNA - Rat Normal Tissue: Small Intestine

C1434226 40 reactions
EUR 578

Monkey (Cyno.) Normal Kidney Whole tissue lysate

MCL-1190 1 mg
EUR 628.8

Human Adult Kidney (Normal) Whole tissue lysate

HAL-1305 1 mg
EUR 628.8

Monkey (Rhesus) Normal Kidney Whole tissue lysate

MRL-1301 1 mg
EUR 628.8

Frozen Tissue Section - Human Adult Normal: Kidney

T1234142 5 slides
EUR 343

Kidney Tumor Tissue Array - 12 cases of kidney cancer paired with adjacent normal tissues

Z7020053 5 slides
EUR 1125.6
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Human Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells

9-80075 1 x 100 ml Ask for price

Mouse Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells

9-80171 1 x 100 ml Ask for price

Paraffin Tissue Section - Human Adult Normal: Kidney

T2234142 5 slides
EUR 185

cDNA - Plant Normal Tissue: cDNA - Plant: Corn

C1634330 40 reactions
EUR 674

cDNA - Plant Normal Tissue: cDNA - Plant: Rice

C1634360 40 reactions
EUR 674

Multiple Kidney cancer tissue array with normal tissue control from autopsy

KD483 each
EUR 168
Description: Multiple Kidney cancer tissue array with normal tissue control from autopsy, 48 cases/48 cores, with stage and grade data

cDNA - Plant Normal Tissue: cDNA - Plant: Wheat

C1634390 40 reactions
EUR 674

cDNA - Human Diabetic Diseased Tissue: Kidney

C1236142Dia 40 reactions
EUR 729

cDNA - Plant Normal Tissue: cDNA - Plant: Orange

C1634340 40 reactions
EUR 674

cDNA - Plant Normal Tissue: cDNA - Plant: Potato

C1634350 40 reactions
EUR 674

Matched Pair - DNA - Human Primary Tumor and Normal Tissue: Kidney

D8235142-PP-10 2x10 ug
EUR 416

cDNA - Dog Normal Tissue: Lung

C1734152 40 reactions
EUR 385

Total RNA - Human Adult Normal Tissue 5 Donor Pool: Kidney

R1234142-P 50 ug
EUR 370

cDNA - Dog Normal Tissue: Brain

C1734035 40 reactions
EUR 385

cDNA - Dog Normal Tissue: Cecum

C1734089 40 reactions
EUR 385

cDNA - Dog Normal Tissue: Heart

C1734122 40 reactions
EUR 385

cDNA - Dog Normal Tissue: Liver

C1734149 40 reactions
EUR 385
Design, synthesis, DNA binding research and analysis of anticancer potential of novel substituted biscarbazole derivatives in opposition to human glioma U87 MG cell line
On this analysis paper, we report the design and synthesis of novel substituted biscarbazole derivatives which had been characterised by 1H and 13C NMR, excessive decision mass spectroscopy (HRMS). The SAR research of the compounds is reported primarily based on completely different substituents and their positions within the biscarbazole scaffold.
In vitro cytotoxicity of the compounds was evaluated in opposition to human glioma U87 MG cell line by MTT assay for 24 h. The IC50 values of the compounds (30-35, 48-53 and 54-62) had been calculated on the focus vary from 1.00 µM to 500 µM. The compound 34 confirmed essentially the most vital in vitro cytotoxicity (IC50 = 3.9 µM) in opposition to human glioma U87 MG cell line and was discovered to be higher than customary medicine used for the therapy of mind tumors akin to temozolomide (IC50 = 100 µM) and carmustine (IC50 = 18.2 µM) respectively.
To find out the mode of binding of compound 34 with CT-DNA, numerous biophysical methods like UV-spectrophotometer, fluorescence, round dichroism, viscosity, topoisomerase assay and molecular docking evaluation, had been used. Our outcomes demonstrated groove binding mode of interplay of the compound 34 with CT-DNA with a believable static bio-molecular quenching fee fixed (Kq) 1.7 × 1012 M-1 s-1. The research of biscarbazole derivatives are anticipated to develop potential novel anticancer brokers in opposition to mind tumors.
Key phrases: BCNU (Carmustine-Bis-Chloro ethyl-NitrosoUrea); CCNU(Lomustine-CyclohexylChloroethylNitrosoUrea); CD (Round Dichroism); CT-DNA (Calf thymus-deoxyribonucleic acid); Compound 34 (bis((6-methoxy-1,4-dimethyl-9H-carbazol-3-yl)methyl) amine); EtBr (Ethidium Bromide); GBM (Glioblastoma); Half most inhibitory focus (IC(50)); Human glioma U87 MG cell line; MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); TMZ (Temozolomide).

DNAJC11 Blocking Peptide

DF12948-BP 1mg
EUR 234

DNAJC11 ELISA KIT|Human

EF009166 96 Tests
EUR 826.8

anti- DNAJC10 antibody

FNab02457 100µg
EUR 658.5
Description: Antibody raised against DNAJC10

anti- DNAJC12 antibody

FNab02459 100µg
EUR 658.5
Description: Antibody raised against DNAJC12

anti- DNAJC15 antibody

FNab02460 100µg
EUR 658.5
Description: Antibody raised against DNAJC15

anti- DNAJC16 antibody

FNab02461 100µg
EUR 658.5
Description: Antibody raised against DNAJC16

anti- DNAJC19 antibody

FNab02462 100µg
EUR 606.3
Description: Antibody raised against DNAJC19

anti- DNAJC21 antibody

FNab02464 100µg
EUR 658.5
Description: Antibody raised against DNAJC21

anti- DNAJC27 antibody

FNab02465 100µg
EUR 658.5
Description: Antibody raised against DNAJC27

Mouse DNAJC11 shRNA Plasmid

20-abx981841
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human DNAJC11 shRNA Plasmid

20-abx960873
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

DNAJC11 Recombinant Protein (Rat)

RP198329 100 ug Ask for price

anti- DNAJC1 antibody

FNab02456 100µg
EUR 606.3
Description: Antibody raised against DNAJC1

anti- DNAJC4 antibody

FNab02466 100µg
EUR 658.5
Description: Antibody raised against DNAJC4

anti- DNAJC7 antibody

FNab02469 100µg
EUR 658.5
Description: Antibody raised against DNAJC7

anti- DNAJC9 antibody

FNab02470 100µg
EUR 702
Description: Antibody raised against DNAJC9

DNAJC11 Recombinant Protein (Human)

RP009565 100 ug Ask for price

DNAJC11 Recombinant Protein (Human)

RP009568 100 ug Ask for price

DNAJC11 Recombinant Protein (Mouse)

RP129536 100 ug Ask for price

Dnajc11 ORF Vector (Rat) (pORF)

ORF066111 1.0 ug DNA
EUR 607.2

DNAJC11 ORF Vector (Human) (pORF)

ORF003189 1.0 ug DNA
EUR 114

DNAJC11 ORF Vector (Human) (pORF)

ORF003190 1.0 ug DNA
EUR 114

Dnajc11 ORF Vector (Mouse) (pORF)

ORF043180 1.0 ug DNA
EUR 607.2

anti- DNAJC5B antibody

FNab02467 100µg
EUR 606.3
Description: Antibody raised against DNAJC5B

anti- DNAJC2/MPP11 antibody

FNab02463 100µg
EUR 606.3
Description: Antibody raised against DNAJC2/MPP11

anti- DNAJC6/AUXILIN antibody

FNab02468 100µg
EUR 658.5
Description: Antibody raised against DNAJC6/AUXILIN

Dnajc11 sgRNA CRISPR Lentivector set (Rat)

K6097801 3 x 1.0 ug
EUR 406.8

Dnajc11 sgRNA CRISPR Lentivector set (Mouse)

K4585501 3 x 1.0 ug
EUR 406.8

DNAJC11 sgRNA CRISPR Lentivector set (Human)

K0615901 3 x 1.0 ug
EUR 406.8

Dnajc11 3'UTR GFP Stable Cell Line

TU155261 1.0 ml Ask for price

DNAJC11 3'UTR GFP Stable Cell Line

TU056152 1.0 ml
EUR 1825.2

Dnajc11 3'UTR GFP Stable Cell Line

TU253519 1.0 ml Ask for price

DNAJC11 Protein Vector (Rat) (pPM-C-HA)

PV264444 500 ng
EUR 723.6

DNAJC11 Protein Vector (Rat) (pPB-C-His)

PV264442 500 ng
EUR 723.6

DNAJC11 Protein Vector (Rat) (pPB-N-His)

PV264443 500 ng
EUR 723.6

DNAJC11 Protein Vector (Rat) (pPM-C-His)

PV264445 500 ng
EUR 723.6

DNAJC11 Protein Vector (Human) (pPM-C-HA)

PV012755 500 ng
EUR 394.8

DNAJC11 Protein Vector (Human) (pPM-C-HA)

PV012759 500 ng
EUR 394.8

DNAJC11 Protein Vector (Mouse) (pPM-C-HA)

PV172720 500 ng
EUR 723.6

DNAJC11 Protein Vector (Human) (pPB-C-His)

PV012753 500 ng
EUR 394.8

DNAJC11 Protein Vector (Human) (pPB-N-His)

PV012754 500 ng
EUR 394.8

DNAJC11 Protein Vector (Human) (pPM-C-His)

PV012756 500 ng
EUR 394.8

DNAJC11 Protein Vector (Human) (pPB-C-His)

PV012757 500 ng
EUR 394.8

DNAJC11 Protein Vector (Human) (pPB-N-His)

PV012758 500 ng
EUR 394.8

DNAJC11 Protein Vector (Human) (pPM-C-His)

PV012760 500 ng
EUR 394.8

DNAJC11 Protein Vector (Mouse) (pPB-C-His)

PV172718 500 ng
EUR 723.6

DNAJC11 Protein Vector (Mouse) (pPB-N-His)

PV172719 500 ng
EUR 723.6

DNAJC11 Protein Vector (Mouse) (pPM-C-His)

PV172721 500 ng
EUR 723.6

DNAJC11 3'UTR Luciferase Stable Cell Line

TU006152 1.0 ml
EUR 1825.2

Dnajc11 3'UTR Luciferase Stable Cell Line

TU105261 1.0 ml Ask for price

Dnajc11 3'UTR Luciferase Stable Cell Line

TU203519 1.0 ml Ask for price

Dnajc11 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6097802 1.0 ug DNA
EUR 184.8

Dnajc11 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6097803 1.0 ug DNA
EUR 184.8

Dnajc11 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6097804 1.0 ug DNA
EUR 184.8

Dnajc11 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4585502 1.0 ug DNA
EUR 184.8

Dnajc11 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4585503 1.0 ug DNA
EUR 184.8

Dnajc11 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4585504 1.0 ug DNA
EUR 184.8

DNAJC11 sgRNA CRISPR Lentivector (Human) (Target 1)

K0615902 1.0 ug DNA
EUR 184.8

DNAJC11 sgRNA CRISPR Lentivector (Human) (Target 2)

K0615903 1.0 ug DNA
EUR 184.8

DNAJC11 sgRNA CRISPR Lentivector (Human) (Target 3)

K0615904 1.0 ug DNA
EUR 184.8

DNAJC17 Antibody

34080-100ul 100ul
EUR 302.4

DNAJC17 Antibody

34080-50ul 50ul
EUR 224.4

DNAJC13 Antibody

8109-002mg 0.02 mg
EUR 206.18
Description: DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans (1). It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles (2). DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor (3).

DNAJC13 Antibody

8109-01mg 0.1 mg
EUR 523.7
Description: DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans (1). It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles (2). DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor (3).

DNAJC19 antibody

70R-9901 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal DNAJC19 antibody

DNAJC10 antibody

70R-16883 50 ul
EUR 522
Description: Rabbit polyclonal DNAJC10 antibody

DNAJC12 antibody

70R-16884 50 ul
EUR 522
Description: Rabbit polyclonal DNAJC12 antibody

DNAJC15 antibody

70R-16885 50 ul
EUR 522
Description: Rabbit polyclonal DNAJC15 antibody

DNAJC16 antibody

70R-16886 50 ul
EUR 522
Description: Rabbit polyclonal DNAJC16 antibody

DNAJC19 antibody

70R-16887 50 ul
EUR 522
Description: Rabbit polyclonal DNAJC19 antibody

DNAJC27 antibody

70R-16889 50 ul
EUR 522
Description: Rabbit polyclonal DNAJC27 antibody

DNAJC25 antibody

70R-6333 50 ug
EUR 560.4
Description: Rabbit polyclonal DNAJC25 antibody

DNAJC10 antibody

70R-6576 50 ug
EUR 560.4
Description: Rabbit polyclonal DNAJC10 antibody

DNAJC17 antibody

70R-32162 100 ug
EUR 392.4
Description: Rabbit polyclonal DNAJC17 antibody

DNAJC12 antibody

70R-3982 50 ug
EUR 560.4
Description: Rabbit polyclonal DNAJC12 antibody

DNAJC17 antibody

70R-51022 100 ul
EUR 292.8
Description: Purified Polyclonal DNAJC17 antibody

DNAJC10 Antibody

35859-100ul 100ul
EUR 302.4

DNAJC15 Antibody

36503-100ul 100ul
EUR 302.4

DNAJC24 antibody

31928-100ul 100ul
EUR 302.4

DNAJC24 antibody

31928-50ul 50ul
EUR 224.4

DNAJC15 Antibody

48789-100ul 100ul
EUR 399.6

DNAJC15 Antibody

48789-50ul 50ul
EUR 286.8

DNAJC14 Antibody

47248-100ul 100ul
EUR 302.4

DNAJC12 Antibody

47360-100ul 100ul
EUR 302.4

DNAJC15 Antibody

ABD2918 100 ug
EUR 525.6

DNAJC17 Antibody

ABD3451 100 ug
EUR 525.6