Molecules that serve similar functions for different organisms

Determination of agrA Gene Transcription In Methicillin-Resistant Staphylococcus Aureus

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

The Fanconi anaemia (FA) pathway is a dedicated pathway for the repair of DNA interstrand crosslinks and is additionally activated in response to other forms of replication stress. A key step in the FA pathway is the monoubiquitination of each of the two subunits (FANCI and FANCD2) of the ID2 complex on specific lysine residues.

However, the molecular function of these modifications has been unknown for nearly two decades. Here, we find that ubiquitination of FANCD2 acts to increase ID2’s affinity for double-stranded DNA via promoting a large-scale conformational change in the complex. The resulting complex encircles DNA, by forming a secondary “Arm” ID2 interface.

Ubiquitination of FANCI, on the other hand, largely protects the ubiquitin on FANCD2 from USP1-UAF1 deubiquitination, with key hydrophobic residues of FANCI’s ubiquitin being important for this protection. In effect, both of these post-translational modifications function to stabilize a conformation in which the ID2 complex encircles DNA.

Keywords: DNA repair; Fanconi anaemia; deubiquitination; protein-DNA interactions; ubiquitin
cdna-clone
cdna-clone

Recombinant Cryptococcus neoformans var. neoformans serotype D Orotate phosphoribosyltransferase (URA5)

RPC25081-20ug 20ug
EUR 479.6

Recombinant Cryptococcus neoformans var. grubii serotype A CMGC/CK2 protein kinase (CNAG_05694)

CSB-EP4205GHUa0 10261 mg Ask for price

Cryptococcus Neoformans Antibody

abx021645-1mg 1 mg
EUR 661.2

Cryptococcus neoformans Antibody

GWB-B6EBB3 1 mg Ask for price

Cryptococcus Neoformans Antibody

abx021645-400l 400 µl Ask for price

Cryptococcus Neoformans Antibody

abx021645-80l 80 µl
EUR 637.5

Cryptococcus neoformans PCR kit

PCR-H691-48D 50T
EUR 543.6

Cryptococcus neoformans PCR kit

PCR-H691-96D 100T
EUR 686.4

Cryptococcus neoformans RT PCR kit

RTq-H691-100D 100T
EUR 860.4

Cryptococcus neoformans RT PCR kit

RTq-H691-150D 150T
EUR 969.6

Cryptococcus neoformans RT PCR kit

RTq-H691-50D 50T
EUR 717.6

Cryptococcus neoformans One-Step PCR kit

Oneq-H691-100D 100T
EUR 1039.2

Cryptococcus neoformans One-Step PCR kit

Oneq-H691-150D 150T
EUR 1177.2

Cryptococcus neoformans One-Step PCR kit

Oneq-H691-50D 50T
EUR 861.6

OAMA02399-1MG - Cryptococcus neoformans Antibody

OAMA02399-1MG 1mg
EUR 449

Cryptococcus neoformans mouse monoclonal antibody, clone 439, Purified

AM31435PU-N 1 mg Ask for price

human anti-Cryptococcus neoformans glucuronoxylomannan(GXM)mAb(B8)

E4A09F13-B8 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-Cryptococcus neoformans glucuronoxylomannan(GXM)mAb(S1)

E4A09F13-S1 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Cryptococcus Capsular Polysaccharide Rapid Test Kit

abx092262-100l 100 µl
EUR 2450

Cryptococcus Capsular Polysaccharide Rapid Test Kit

abx092262-1ml 1 ml
EUR 32500

Cryptococcus Capsular Polysaccharide Rapid Test Kit

abx092262-200l 200 µl
EUR 8400

Mouse Anti-C. neoformans Monoclonal antibody, clone 540

CABT-RM274 1 mg
EUR 733.2

Mouse Anti-C. neoformans GXM Monoclonal antibody, clone 29C8

CABT-CS987 200 μg
EUR 720
Description: Mouse

Rabbit Anti-C. neoformans GXM Monoclonal antibody, clone 29C8

CABT-CS988 200 μg
EUR 720
Description: Rabbit

QPCR Kit DNA Cryptococcu - EACH

MOL8452 EACH
EUR 1129.51

QPCR Kit DNA Cryptococcu Mmix - EACH

MOL8454 EACH
EUR 1433.55

genesig Real-time PCR detection kit for C.neoformans

Z-Path-C-neoformans 150 tests
EUR 808
Description: C.neoformans

Streptococcus pyogenes serotype M5 M protein, serotype 5 (emm5)

1-CSB-EP355917SMY
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  • 1MG
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  • 500ug
  • 50ug
Description: Recombinant Streptococcus pyogenes serotype M5 M protein, serotype 5(emm5) expressed in E.coli

Recombinant Streptococcus pyogenes serotype M5 M protein, serotype 5(emm5)

AP74234 1mg
EUR 2826

Recombinant Streptococcus pyogenes serotype M5 M protein, serotype 5 (emm5)

CSB-EP355917SMY 3209 mg Ask for price

AAV Serotype Blast™ Kit

AAV099 9 x 100 μl
EUR 645

Bluetongue virus serotype 4

PCR-V233-PCRV23348R PCR-V233-48R
EUR 485

Bluetongue virus serotype 4

PCR-V233-PCRV23396R PCR-V233-96R
EUR 685

Bluetongue virus serotype 4

Oneq-V233-OneqV233100R Oneq-V233-100R
EUR 1028

Bluetongue virus serotype 4

Oneq-V233-OneqV233150R Oneq-V233-150R
EUR 1438

Bluetongue virus serotype 4

Oneq-V233-OneqV23350R Oneq-V233-50R
EUR 728

FliC, Serotype a (427-441), S.paratyphi A

TP1703-10mg 10mg Ask for price
Description: FliC, Serotype a (427-441), S.paratyphi A

FliC, Serotype a (427-441), S.paratyphi A

TP1703-1g 1g Ask for price
Description: FliC, Serotype a (427-441), S.paratyphi A

FliC, Serotype a (427-441), S.paratyphi A

TP1703-1mg 1mg Ask for price
Description: FliC, Serotype a (427-441), S.paratyphi A

FliC, Serotype a (427-441), S.paratyphi A

TP1703-50mg 50mg Ask for price
Description: FliC, Serotype a (427-441), S.paratyphi A

FliC, Serotype a (427-441), S.paratyphi A

TP1703-5mg 5mg Ask for price
Description: FliC, Serotype a (427-441), S.paratyphi A

Dengue Virus Serotype 1 VLP

DENV1-VLP-100 0.1
EUR 400.23
Description: Recombinant Dengue Virus serotype 1 virus-like particle recombinant antigen consisting of Envelope, pre-Membrane and Membrane protein produced in 293 human cells. The C-terminal 20% of the dengue Envelope protein was replaced by the corresponding Japanese encephalitis virus SA-14 sequence (Envelope protein amino acids 399-497). The replaced sequence corresponds to the transmembrane and intraparticle portion of the protein.

Dengue Virus Serotype 1 VLP

DENV1-VLP-500 0.5
EUR 1701
Description: Recombinant Dengue Virus serotype 1 virus-like particle recombinant antigen consisting of Envelope, pre-Membrane and Membrane protein produced in 293 human cells. The C-terminal 20% of the dengue Envelope protein was replaced by the corresponding Japanese encephalitis virus SA-14 sequence (Envelope protein amino acids 399-497). The replaced sequence corresponds to the transmembrane and intraparticle portion of the protein.

Dengue Virus Serotype 2 VLP

DENV2-VLP-100 0.1
EUR 400.23
Description: Recombinant Dengue Virus serotype 2 virus-like particle recombinant antigen consisting of Envelope, pre-Membrane and Membrane protein produced in 293 human cells. The C-terminal 20% of the dengue Envelope protein was replaced by the corresponding Japanese encephalitis virus SA-14 sequence (Envelope protein amino acids 397-495). The replaced sequence corresponds to the transmembrane and intraparticle portion of the protein.

Dengue Virus Serotype 2 VLP

DENV2-VLP-500 0.5
EUR 1701
Description: Recombinant Dengue Virus serotype 2 virus-like particle recombinant antigen consisting of Envelope, pre-Membrane and Membrane protein produced in 293 human cells. The C-terminal 20% of the dengue Envelope protein was replaced by the corresponding Japanese encephalitis virus SA-14 sequence (Envelope protein amino acids 397-495). The replaced sequence corresponds to the transmembrane and intraparticle portion of the protein.

Dengue Virus Serotype 3 VLP

DENV3-VLP-100 0.1
EUR 400.23
Description: Recombinant Dengue Virus serotype 3 virus-like particle recombinant antigen consisting of Envelope, pre-Membrane and Membrane protein produced in 293 human cells. The C-terminal 20% of the dengue Envelope protein was replaced by the corresponding Japanese encephalitis virus SA-14 sequence (Envelope protein amino acids 399-492). The replaced sequence corresponds to the transmembrane and intraparticle portion of the protein.

Dengue Virus Serotype 3 VLP

DENV3-VLP-500 0.5
EUR 1701
Description: Recombinant Dengue Virus serotype 3 virus-like particle recombinant antigen consisting of Envelope, pre-Membrane and Membrane protein produced in 293 human cells. The C-terminal 20% of the dengue Envelope protein was replaced by the corresponding Japanese encephalitis virus SA-14 sequence (Envelope protein amino acids 399-492). The replaced sequence corresponds to the transmembrane and intraparticle portion of the protein.

Dengue Virus Serotype 4 VLP

DENV4-VLP-100 0.1
EUR 400.23
Description: Recombinant Dengue Virus serotype 4 virus-like particle recombinant antigen consisting of Envelope, pre-Membrane and Membrane protein produced in 293 human cells. The C-terminal 20% of the dengue Envelope protein was replaced by the corresponding Japanese encephalitis virus SA-14 sequence (Envelope protein amino acids 400-495). The replaced sequence corresponds to the transmembrane and intraparticle portion of the protein.

Dengue Virus Serotype 4 VLP

DENV4-VLP-500 0.5
EUR 1701
Description: Recombinant Dengue Virus serotype 4 virus-like particle recombinant antigen consisting of Envelope, pre-Membrane and Membrane protein produced in 293 human cells. The C-terminal 20% of the dengue Envelope protein was replaced by the corresponding Japanese encephalitis virus SA-14 sequence (Envelope protein amino acids 400-495). The replaced sequence corresponds to the transmembrane and intraparticle portion of the protein.

Astrovirus (SEROTYPE 1) Antibody

GWB-419AD7 0.2 mg Ask for price

Astrovirus (SEROTYPE 1) Antibody

GWB-22040C 0.2 mg Ask for price

Astrovirus (SEROTYPE 1) Antibody

GWB-27AA23 0.2 mg Ask for price

AAV Packaging Mix (Serotype 1)

AAV1001 100 µg
EUR 395

AAV Packaging Mix (Serotype 2)

AAV1002 100 µg
EUR 395

AAV Packaging Mix (Serotype 3)

AAV1003 100 µg
EUR 395

AAV Packaging Mix (Serotype 4)

AAV1004 100 µg
EUR 395

AAV Packaging Mix (Serotype 5)

AAV1005 100 µg
EUR 395

AAV Packaging Mix (Serotype 6)

AAV1006 100 µg
EUR 395

FMD Virus Serotype 01 Antibody

abx021717-1mg 1 mg
EUR 878.4

Dengue NS1 protein (Serotype 1)

30-1844 250 ug
EUR 363
Description: Purified recombinant Dengue NS1 protein (Serotype 1)

Dengue NS1 protein (Serotype 3)

30-1846 250 ug
EUR 363
Description: Purified recombinant Dengue NS1 protein (Serotype 3)

Dengue NS1 protein (Serotype 4)

30-1847 250 ug
EUR 363
Description: Purified recombinant Dengue NS1 protein (Serotype 4)

Dengue NS1 protein (Serotype 2)

30-1909 250 ug
EUR 363
Description: Purified recombinant Dengue NS1 protein (Serotype 2)

Dengue NS1 protein (Serotype 1)

80-1536 100 ug
EUR 443
Description: Purified recombinant Dengue NS1 protein (Serotype 1) (His tag)

Dengue NS1 protein (Serotype 2)

80-1537 100 ug
EUR 434
Description: Purified recombinant Dengue NS1 protein (Serotype 2) (His tag)

Dengue VLP protein (Serotype 2)

80-1538 100 ug
EUR 1285
Description: Purified recombinant Dengue VLP protein (Serotype 2) (His tag)

Dengue NS1 protein (Serotype 3)

80-1539 100 ug
EUR 812
Description: Purified recombinant Dengue NS1 protein (Serotype 3) (His tag)

Dengue VLP protein (Serotype 3)

80-1540 100 ug
EUR 1534
Description: Purified recombinant Dengue VLP protein (Serotype 3) (His tag)

Dengue NS1 protein (Serotype 4)

80-1541 100 ug
EUR 567
Description: Purified recombinant Dengue NS1 protein (Serotype 4) (His tag)

Dengue Virus Lysate, Serotype 2

NAT41569-100 0.1
EUR 1247.4
Description: Dengue virus Serotype 2 is propagated in the Vero cell line. Following culture, the virus is purified by sucrose density gradient ultracentrifugation. Purified virions were lysed in 0.6M KCl containing 0.5% Triton X-100, and then subjected to heat inactivation.

Serotype 2 fimbriasubunit Antibody

20-abx110520
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
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Serotype 2 fimbriasubunit Antibody

abx110520-100l 100 µl
EUR 162.5

Avian influenza virus, serotype H7

PCR-V047-PCRV04748R PCR-V047-48R
EUR 485

Avian influenza virus, serotype H7

PCR-V047-PCRV04796R PCR-V047-96R
EUR 685

Avian influenza virus, serotype H9

PCR-V048-PCRV04848R PCR-V048-48R
EUR 485

Avian influenza virus, serotype H9

PCR-V048-PCRV04896R PCR-V048-96R
EUR 685

Avian influenza virus, serotype H7

Oneq-V047-OneqV047100R Oneq-V047-100R
EUR 1028

Avian influenza virus, serotype H7

Oneq-V047-OneqV047150R Oneq-V047-150R
EUR 1438

Fluorometric determination of agrA gene transcription in methicillin-resistant Staphylococcus aureus with a graphene oxide-based assay using strand-displacement polymerization recycling and hybridization chain reaction

A graphene oxide (GO)-based fluorescent bioassay was developed to quantify agrA gene transcription (its mRNA) in methicillin-resistant Staphylococcus aureus (MRSA). This method is based on the use of Klenow fragment (KF)-assisted target recycling amplification and hybridization chain reaction (HCR). A triple complex was designed that contained a capture probe (CP), a trigger probe (TP), and a help probe (HP), which were partially complementary to one another.
In the absence of the target, all the oligonucleotides labeled with carboxyfluorescein (FAM) are adsorbed onto the surface of GO by π-stacking interactions. This adsorption quenches the FAM signal. On the contrary, the target RNA causes the triple complex to disintegrate and initiates strand-displacement polymerization reaction (SDPR) and HCR in the presence of the appropriate raw materials, including the primer, KF, dNTPs, hairpin 1 (H1), and hairpin 2 (H2), generating double-stranded DNA (dsDNA) products.
These dsDNA products are repelled by GO and produce strong fluorescence, measured at excitation/emission wavelengths of 480/514 nm. The fluorescent signal is greatly amplified by SYBR Green I (SGI) due to the synergistic effect of dsDNA-SGI. The target was assayed with this method at concentrations in the range 10 fM to 100 pM, and the detection limit (LOD) was 10 fM.
This method also displayed good applicability in the analysis of real samples. It provides a new way of monitoring biofilm formation and studying the mechanisms of drug actions. Graphical abstract Schematic representation of the graphene oxide-based fluorescent bioassay for agrA gene transcription in methicillin-resistant Staphylococcus aureus by using strand-displacement polymerization recycling and hybridization chain reaction.
Keywords: Biofilms; Drug-resistant bacteria; Dual fluorescence; Enzymatic reaction; Fluorescent assay; Quenching

The structure of human CST reveals a decameric assembly bound to telomeric DNA

The CTC1-STN1-TEN1 (CST) complex is essential for telomere maintenance and resolution of stalled replication forks genome-wide. Here, we report the 3.0-angstrom cryo-electron microscopy structure of human CST bound to telomeric single-stranded DNA (ssDNA), which assembles as a decameric supercomplex.
The atomic model of the 134-kilodalton CTC1 subunit, built almost entirely de novo, reveals the overall architecture of CST and the DNA-binding anchor site. The carboxyl-terminal domain of STN1 interacts with CTC1 at two separate docking sites, allowing allosteric mediation of CST decamer assembly. Furthermore, ssDNA appears to staple two monomers to nucleate decamer assembly.
CTC1 has stronger structural similarity to Replication Protein A than the expected similarity to yeast Cdc13. The decameric structure suggests that CST can organize ssDNA analogously to the nucleosome’s organization of double-stranded DNA.

Rye Genomic DNA

PLG-1097 0.1mg
EUR 307

Pea Genomic DNA

PLG-1141 0.1mg
EUR 307

Cat Genomic DNA

GC-130 0.1mg
EUR 177

Genomic DNA Kit

abx098076-100l 100 µl
EUR 300

Genomic DNA Kit

abx098076-1ml 1 ml Ask for price

Genomic DNA Kit

abx098076-200l 200 µl
EUR 550

Clam Genomic DNA

GCL-325 0.025mg
EUR 177

Duck Genomic DNA

GD-220 0.1mg
EUR 177

Goat Genomic DNA

GG-150 0.1mg
EUR 177

Pork Genomic DNA

PCR-705 20µg
EUR 90.1

Corn Genomic DNA

PLG-1002 0.1mg
EUR 307

Rice Genomic DNA

PLG-1004 0.1mg
EUR 307

Pear Genomic DNA

PLG-1033 0.1mg
EUR 307

Crab Genomic DNA

GRA-340 0.025mg
EUR 177

Human Genomic DNA

BIO-35025 500µl @ 200ng/µl Ask for price

Llama genomic DNA

GL-260 0.1mg
EUR 177

Yeast Genomic DNA*

GY-300 0.05mg
EUR 177

Ecoli Genomic DNA*

GE-310 0.05mg
EUR 177

Goose Genomic DNA

GG-140 0.1mg
EUR 177

Human Genomic DNA

PCR-261 20µg
EUR 96

Horse Genomic DNA

PCR-706 20µg
EUR 90.1

Apple Genomic DNA

PLG-1001 0.1mg
EUR 307

Beans Genomic DNA

PLG-1051 0.1mg
EUR 307

Lemon Genomic DNA

PLG-1062 0.1mg
EUR 307

Wheat Genomic DNA

PLG-1084 0.1mg
EUR 307

Onion Genomic DNA

PLG-1092 0.1mg
EUR 307

Maple Genomic DNA

PLG-1094 0.1mg
EUR 307

Lotus Genomic DNA

PLG-1161 0.1mg
EUR 307

Quail Genomic DNA

GQ-200 0.1mg
EUR 177

Camel Genomic DNA

GC-270 0.1mg
EUR 177

Squid Genomic DNA

GSQ-380 0.025mg
EUR 177

Human Genomic DNA 

X11000
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  • 0.2 ml
  • 0.2 ml

Donkey Genomic DNA

GD-160 0.1mg
EUR 177

Ferret Genomic DNA*

GF-180 0.05mg
EUR 177

Gerbil Genomic DNA*

GG-120 0.05mg
EUR 177

Shirmp Genomic DNA

GHR-375 0.025mg
EUR 177

Orange Genomic DNA

PLG-1003 0.1mg
EUR 307

Cotton Genomic DNA

PLG-1022 0.1mg
EUR 307

Banana Genomic DNA

PLG-1031 0.1mg
EUR 307

Barley Genomic DNA

PLG-1041 0.1mg
EUR 307

Pepper Genomic DNA

PLG-1043 0.1mg
EUR 307

Potato Genomic DNA

PLG-1073 0.1mg
EUR 307

Tomato Genomic DNA

PLG-1074 0.1mg
EUR 307

Carrot Genomic DNA

PLG-1081 0.1mg
EUR 307

Radish Genomic DNA

PLG-1083 0.1mg
EUR 307

Cherry Genomic DNA

PLG-1091 0.1mg
EUR 307

Squash Genomic DNA

PLG-1111 0.1mg
EUR 307

Lentil Genomic DNA

PLG-1151 0.1mg
EUR 307

Oyster Genomic DNA

GOY-330 0.025mg
EUR 177

Pigeon Genomic DNA

GP-210 0.1mg
EUR 177

Turkey Genomic DNA

GT-150 0.1mg
EUR 177

Alpaca Genomic DNA

GAP-260 0.1mg
EUR 177

Catfish Genomic DNA

GFC-190 0.025mg
EUR 177

Lobster Genomic DNA

GLB-370 0.025mg
EUR 177

Apricot Genomic DNA

PLG-1011 0.1mg
EUR 307

Soybean Genomic DNA

PLG-1044 0.1mg
EUR 307

Spinach Genomic DNA

PLG-1054 0.1mg
EUR 307

Cabbage Genomic DNA

PLG-1071 0.1mg
EUR 307

Lettuce Genomic DNA

PLG-1072 0.1mg
EUR 307

Ginseng Genomic DNA

PLG-1088 0.05mg
EUR 307

Tobacco Genomic DNA

PLG-1101 0.1mg
EUR 307

Mussels Genomic DNA

GMU-345 0.025mg
EUR 177

Ostrich Genomic DNA

GO-320 0.1mg
EUR 177

Crawfish Genomic DNA

GCF-405 0.025mg
EUR 177

Wildboar Genomic DNA

GW-250 0.1mg
EUR 177

Cucumber Genomic DNA

PLG-1032 0.1mg
EUR 307

Broccoli Genomic DNA

PLG-1061 0.1mg
EUR 307

Rapeseed Genomic DNA

PLG-1093 0.1mg
EUR 307

Flaxseed Genomic DNA

PLG-1095 0.1mg
EUR 307

Chickpea Genomic DNA

PLG-1121 0.1mg
EUR 307

Silkworm Genomic DNA*

GK-390 0.025mg
EUR 177

Starfish Genomic DNA

GSF-390 0.025mg
EUR 177

Alligator Genomic DNA

GL-100 0.025mg
EUR 177

Zebrafish Genomic DNA

GZ-270 0.025mg
EUR 177

Persimmon Genomic DNA

PLG-1053 0.1mg
EUR 307

Sunflower Genomic DNA

PLG-1064 0.1mg
EUR 307

Nectarine Genomic DNA

PLG-1082 0.1mg
EUR 307

Asparagus Genomic DNA

PLG-1131 0.1mg
EUR 307

Jellyfish Genomic DNA

GJF-365 0.025mg
EUR 177

Drosophila Genomic DNA*

GD-290 0.025mg
EUR 177

Salmonella Genomic DNA

MBT103-250R 1 unit
EUR 119.62
Description: Salmonella Genomic DNA

Arabidopsis Genomic DNA

PLG-1021 0.05mg
EUR 307

Dog Skin Genomic DNA

DG-101 0.1mg
EUR 210

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