Molecules that serve similar functions for different organisms

Overexpression of the complementary DNA for human glutamine:fructose-6-phosphate amidotransferase in mesangial cells enhances glucose-induced fibronectin synthesis and transcription factor cyclic adenosine monophosphate-responsive element binding phosphorylation.

Hyperglycemia-induced alterations in mesangial cell perform and extracellular matrix protein (ECM) accumulation are seen in diabetic glomerulopathy. The hexosamine biosynthesis pathway (HBP) is implicated in mediating a number of metabolic results of excessive glucose (HG)…Continue Reading