Molecules that serve similar functions for different organisms

Resonance Imaging at Initial Tumor Diagnosis With the Prognosis of Different Molecular Glioma Subtypes

Resonance Imaging at Initial Tumor Diagnosis With the Prognosis of Different Molecular Glioma Subtypes

cdna-clone

Affiliation of Dynamic Susceptibility Magnetic Resonance Imaging at Preliminary Tumor Prognosis With the Prognosis of Completely different Molecular Glioma Subtypes

Objective: The up to date 2016 CNS World Well being Group classification differentiates three predominant teams of diffuse glioma in keeping with their molecular traits: astrocytic tumors with and with out isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deleted oligodendrogliomas.
The current research aimed to find out whether or not dynamic susceptibility distinction magnetic resonance imaging (DSC-MRI) is an unbiased prognostic marker inside the molecular subgroups of diffuse glioma.
Strategies: Fifty-six sufferers with treatment-naive gliomas and superior preoperative MRI examination have been assessed retrospectively. The imply and maximal normalized cerebral blood quantity values from DSC-MRI inside the tumors have been measured. Optimum cutoff values for the 1-year progression-free survival (PFS) have been outlined, and Kaplan-Meier analyses have been carried out individually for the three glioma subgroups.
Outcomes: IDH wild-type astrocytic tumors had the next imply and maximal perfusion than IDH-mutant astrocytic tumors and oligodendrogliomas. Sufferers with IDH wild-type astrocytic tumors and a low imply or maximal perfusion had a considerably shorter PFS than sufferers of the identical group with excessive perfusion (p = 0.0159/0.0112).
Moreover, that they had a considerably larger threat for early development (hazard ratio = 5.6/5.1). This discovering was unbiased of the methylation standing of O6-methylguanin-DNA-methyltransferase and variations of the remedy. Throughout the teams of IDH-mutant astrocytic tumors and oligodendrogliomas, the PFS of low and extremely perfused tumors didn’t differ.
Conclusion: Excessive perfusion upon preliminary analysis is just not compellingly related to worse short-term prognosis inside the totally different molecular subgroups of diffuse glioma. Significantly, the general extremely perfused group of IDH wild-type astrocytic tumors accommodates tumors with low perfusion however unfavorable prognosis.
Key phrases: DSC-MRI; Glioma; IDH mutation; Molecular; Perfusion; prognosis
cdna-clone
cdna-clone

Anti-Myc magnetic beads

B26301 1 mL
EUR 579.6
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification.

Anti-Myc magnetic beads

B26302 5 mL
EUR 1742.4
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification.

Anti-HA Magnetic Beads

HY-K0201 1 mL
EUR 334.8

Protein A Magnetic Beads

HY-K0203 1 mL
EUR 148.8

Protein G Magnetic Beads

HY-K0204 5 mL
EUR 445.2

Anti-Flag Magnetic Beads

HY-K0207 1 mL
EUR 570

Protein A Magnetic Beads

6507-1 each
EUR 314.4

Protein G Magnetic Beads

6517-1 each
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Protein L Magnetic Beads

6537-1 each
EUR 352.8

Protein A/G Magnetic Beads

HY-K0202 1 mL
EUR 157.2

Anti-c-Myc Magnetic Beads

HY-K0206 5 mL
EUR 1368

Protein A/G Magnetic Beads

6527-1 each
EUR 352.8

Size Selection DNA Beads

20-abx298001
  • EUR 260.40
  • EUR 477.60
  • EUR 1663.20
  • 1 ml
  • 5 ml
  • 60 ml

VAHTS DNA Clean Beads

N411-01 5 ml
EUR 259.2

VAHTS DNA Clean Beads

N411-02 60 ml
EUR 634.8

VAHTS DNA Clean Beads

N411-03 450 ml
EUR 3055.2

Protein A/G/L Magnetic Beads

6547-1 each
EUR 405.6

Protein A/G Magnetic Beads for IP

B23201 1 ml
EUR 158.4
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens.

Protein A/G Magnetic Beads for IP

B23202 5 ml
EUR 558
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens.

Protein A Beads (1-2mg/ml)

B0001-10 10ml
EUR 486

Protein A Beads (1-2mg/ml)

B0001-25 25ml
EUR 973.2

Protein A Beads (1-2mg/ml)

B0001-5 5ml
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Protein G Beads (1-2mg/ml)

B0002-10 10ml
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Protein G Beads (1-2mg/ml)

B0002-25 25ml
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Protein G Beads (1-2mg/ml)

B0002-5 5ml
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100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP 1/pk
EUR 87.6
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT

M-DNA-1KB 1/pk
EUR 84
Description: Bioscience Mol Bio; DNA Ladder

Bottle Centrifuge Pp 450 Ml

3141-0500 PK4
EUR 152.76

Magnetic Beads-conjugated Mouse anti DDDDK-Tag mAb

AE037 50 ul
EUR 211.2

Beads-for-Seeds (24 glass beads, each in a 1.5 ml tube)

M-CO-501 24 glass beads
EUR 71
Description: Beads-for-Seeds (24 glass beads, each in a 1.5 ml tube)

FAB & Beads(Ballotini Beads)

MED1042 PK50
EUR 91.2

Goat Anti-Rabbit IgG Beads (1-1.5mg/ml)

B0003-10 10ml
EUR 681.6

Goat Anti-Rabbit IgG Beads (1-1.5mg/ml)

B0003-25 25ml
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Goat Anti-Rabbit IgG Beads (1-1.5mg/ml)

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Goat Anti-Mouse IgG Beads (1-1.5mg/ml)

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Goat Anti-Mouse IgG Beads (1-1.5mg/ml)

B0004-25 25ml
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Goat Anti-Mouse IgG Beads (1-1.5mg/ml)

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Rabbit Anti-Human IgG Beads (1-1.5mg/ml)

B0005-10 10ml
EUR 949.2

Rabbit Anti-Human IgG Beads (1-1.5mg/ml)

B0005-25 25ml
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Rabbit Anti-Human IgG Beads (1-1.5mg/ml)

B0005-5 5ml
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Rabbit Anti-Rat IgG Beads (1-1.5mg/ml)

B0006-10 10ml
EUR 949.2

Rabbit Anti-Rat IgG Beads (1-1.5mg/ml)

B0006-25 25ml
EUR 2008.8

Rabbit Anti-Rat IgG Beads (1-1.5mg/ml)

B0006-5 5ml
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Mouse Anti-Rabbit IgG Beads (1-1.5mg/ml)

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Mouse Anti-Rabbit IgG Beads (1-1.5mg/ml)

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Mouse Anti-Rabbit IgG Beads (1-1.5mg/ml)

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Mouse Anti-Human IgG Beads (1-1.5mg/ml)

B0008-10 10ml
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Mouse Anti-Human IgG Beads (1-1.5mg/ml)

B0008-25 25ml
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Mouse Anti-Human IgG Beads (1-1.5mg/ml)

B0008-5 5ml
EUR 547.2

Circulating DNA Kit (with Magnetic Stand)

abx098869-50rxns 50 rxns
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Circulating DNA Kit (with Magnetic Stand)

abx298026-50rxns 50 rxns
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RNA/DNA Purification Kit (Magnetic Bead)

DA0623 32 test/kit Ask for price

Cyanine7 tetrazine, 25 mg

450 25 mg
EUR 615.6

Blood Genomic DNA Kit (with Magnetic Stand)

abx098867-50rxns 50 rxns
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Viral DNA / RNA Kit (with Magnetic Stand)

abx098871-50rxns 50 rxns
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Viral DNA/RNA Kit (with Magnetic Stand)

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Latex Beads

abx291003-1L 1 L
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RNA Beads

20-abx298002
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  • 1 ml
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  • 60 ml

Bulk Beads

D1131-01 1 PC
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Bulk Beads

D1131-05 1 PC
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Bulk Beads

D1131-10 1 PC
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Bulk Beads

D1132-01TP 1 PC
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Bulk Beads

D1132-05TP 1 PC
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Bulk Beads

D1132-15TP 1 PC
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Bulk Beads

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Bulk Beads

D1132-60 1 PC
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Bulk Beads

D1133-28 1 PC
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Exorose Beads

EXOB-100 100 ml
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Exorose Beads

EXOB-25 25 ml
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Exorose Beads

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Saline & Beads

MED1064 PK50
EUR 91.2

T4 DNA Polymerase (5,000 U/ml)

RK20539 25 U Ask for price

Refill Glass Beads

B1201-BEAD 1 PC
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V5 agarose beads

AE029-100ul 100 ul Ask for price

V5 agarose beads

AE029-200ul 200 ul
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V5 agarose beads

AE029-20ul 20 ul Ask for price
Plasmacytoid Dendritic Cells and Kind I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA
Class-switched antibodies to double-stranded DNA (dsDNA) are prevalent and pathogenic in systemic lupus erythematosus (SLE), but mechanisms of their growth stay poorly understood. People and mice missing secreted DNase DNASE1L3 develop speedy anti-dsDNA antibody responses and SLE-like illness.
We report that anti-DNA responses in Dnase1l3-/- mice require CD40L-mediated T cell assist, however proceed independently of germinal middle formation by way of short-lived antibody-forming cells (AFCs) localized to extrafollicular areas. Kind I interferon (IFN-I) signaling and IFN-I-producing plasmacytoid dendritic cells (pDCs) facilitate the differentiation of DNA-reactive AFCs in vivo and in vitro and are required for downstream manifestations of autoimmunity.
Furthermore, the endosomal DNA sensor TLR9 promotes anti-dsDNA responses and SLE-like illness in Dnase1l3-/- mice redundantly with one other nucleic acid-sensing receptor, TLR7. These outcomes set up extrafollicular B cell differentiation into short-lived AFCs as a key mechanism of anti-DNA autoreactivity and reveal a significant contribution of pDCs, endosomal Toll-like receptors (TLRs), and IFN-I to this pathway.
Key phrases: DNASE1L3; TLR7; TLR9; anti-DNA antibodies; extrafollicular B cell response; plasmacytoid dendritic cells; systemic lupus erythematosus; sort I interferon.
Impact on Close to-Infrared Absorption Spectra of DNA/single-walled Carbon Nanotube (SWNT) Complexes by Adsorption of a Blocking Reagent
On this research, we investigated whether or not the adsorption or coating of single-walled carbon nanotubes (SWNTs) with a blocking reagent would forestall the oxidation and discount of SWNTs. Blocking reagents are broadly utilized in life sciences to guard coated molecules from adsorption by different molecules.
A posh of dsDNA-SWNT advanced (Complicated A) was ready by mixing SWNTs powder with dsDNA resolution of deoxyribonucleic acid and sodium salt from salmon testes. Blocking reagent (DB1130) was added to Complicated A to a closing focus of 1% to arrange a dsDNA-SWNT-DB1130 advanced (Complicated B).
Complicated B was sonicated to arrange a dsDNA-SWNT-DB1130-s advanced (Complicated C). Every advanced was oxidized with 0.03 % hydrogen peroxide (H2O2), after which the catechin resolution, which has an anti-oxidative impact, was added to the pattern.
For Complicated A, the peak of the absorption spectra peak decreased with the addition of H2O2, and was recovered with the addition of catechin. In Complicated B, the magnitude of change within the absorption peak top was smaller than that in Complicated A, and no important change was detected in Complicated C.
These outcomes point out that DB1130 blocks the redox motion of SWNTs, and this impact turns into stronger with rising DB1130 adsorption. We discovered that whereas the distinction within the ranges of DB1130 adsorption didn’t have an effect on the absorbance considerably, it induces in a big change in photoluminescence depth.
Moreover, ultrasonic therapy brought about the substitute of dsDNA by DB1130 in Complicated B, leading to a rise within the quantity of adsorption, and rising the diameter of SWNTs. This was additionally confirmed by Atomic Pressure Microscopy (AFM) measurements.
Key phrases: Blocking reagent; Carbon nanotube; DNA; Close to-infrared; Photoluminescence; Redox

QPCR Kit DNA Universal m Mmix

MOL6612 EACH
EUR 1127.46

Methylamp Universal Methylated DNA Preparation Kit

P-1019 40 µg
EUR 416.7

2K DNA Marker

20-abx098045
  • EUR 309.60
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15K DNA Marker

20-abx098049
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1Kb DNA Marker

20-abx098050
  • EUR 309.60
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  • 2.5 ml
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100bp DNA Marker

20-abx098052
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  • EUR 226.80
  • 2.5 ml
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100bp DNA Marker

D1100-050 50㎍
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100bp DNA Marker

D1100-250 5X50㎍
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1Kb DNA Marker

D1101-050 50㎍
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1Kb DNA Marker

D1101-250 5X50㎍
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DL5000 DNA Marker

MD102-01 250 μl
EUR 128.4

DL5000 DNA Marker

MD102-02 500 μl
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DL15000 DNA Marker

MD103-01 250 μl
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DL15000 DNA Marker

MD103-02 500 μl
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Genorise® Universal DNA Mini Kit 50

GR101076 50
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Genorise® Universal DNA Mini Kit 100

GR101076-100 100
EUR 428.4

Genorise® Universal DNA Mini Kit 200

GR101077 200
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Genorise® Universal DNA Mini Kit 500

GR101077-500 500
EUR 1526.4

EpiMag High Throughput DNA Isolation Universal Kit

P-1022-96 96 Samples
EUR 227.7

VAHTS Universal DNA Library Prep Kit for MGI

NDM607-01 24 rxn
EUR 879.6

VAHTS Universal DNA Library Prep Kit for MGI

NDM607-02 96 rxn
EUR 2563.2

1Kb Plus DNA Marker

20-abx098051
  • EUR 360.00
  • EUR 243.60
  • 2.5 ml
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DL2000 Plus DNA Marker

MD101-01 250 μl
EUR 128.4

DL2000 Plus DNA Marker

MD101-02 500 μl
EUR 135.6

Linear Kinetoplast DNA Marker

TG2018-1 10 ug
EUR 214.8

Decatenated Kinetoplast DNA Marker

TG2020-1 10 ug
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Relaxed pRYG DNA Marker

TG2025-1 10 ug
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Linear pRYG DNA Marker

TG2028-1 10 ug
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VAHTS Universal DNA Library Prep Kit for Illumina V3

ND607-01 24 rxn
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VAHTS Universal DNA Library Prep Kit for Illumina V3

ND607-02 96 rxn
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VAHTS Universal Pro DNA Library Prep Kit for Illumina

ND608-01 24 rxn
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VAHTS Universal Pro DNA Library Prep Kit for Illumina

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VAHTS Universal Plus DNA Library Prep Kit for Illumina

ND617-01 24 rxn
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VAHTS Universal Plus DNA Library Prep Kit for Illumina

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VAHTS Universal DNA Library Prep Kit for Ion Torrent

ND701-01 24 rxn
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VAHTS Universal DNA Library Prep Kit for Ion Torrent

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VAHTS Universal Pro DNA Library Prep Kit for MGI

NDM608-01 24 rxn
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VAHTS Universal Pro DNA Library Prep Kit for MGI

NDM608-02 96 rxn
EUR 2740.8

VAHTS Universal Plus DNA Library Prep Kit for MGI

NDM617-01 24 rxn
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VAHTS Universal Plus DNA Library Prep Kit for MGI

NDM617-02 96 rxn
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1 Kb Ladder DNA Marker

FYD001-500UL 20 µg/ 500 µl Ask for price

100 bp Ladder DNA Marker

FYD002-500UL 30 µg/ 500 µl Ask for price

50 bp Ladder DNA Marker

FYD004-500UL 32.5 µg/ 500 µl Ask for price

Universal platform

INC1112 EACH
EUR 1265.4

Universal Attachment

MIX1320 EACH
EUR 272.46

500-10000bp DNA Marker, Original Form

M101O-1 100loading, 100prep
EUR 110.11

500-10000bp DNA Marker, Original Form

M101O-2 5x100loading, 500prep
EUR 263.58

100-1500bp DNA Marker, Original Form

M102O-1 100loading, 100prep
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100-1500bp DNA Marker, Original Form

M102O-2 5x100loading, 500prep
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100-1500bp DNA Marker, Original Form

M107O-1 100loading, 100prep
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100-1500bp DNA Marker, Original Form

M107O-2 5x100loading, 500prep
EUR 263.58

50-500bp Low Range DNA Marker

GM305 200loading, 200prep
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Image Green? 100 bp DNA Marker

M1155-500 each
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Image Green? 1 kb DNA Marker

M1156-500 each
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VAHTS Universal DNA Library Prep Kit for Illumina V3 (PCR-Free)

ND607-03 24 rxn
EUR 514.8

VAHTS Universal DNA Library Prep Kit for Illumina V3 (PCR-Free)

ND607-04 96 rxn
EUR 1624.8

2K Plus DNA Marker (8 linear double-stranded DNA bands)

20-abx098046
  • EUR 309.60
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2K Plus DNA Marker (9 linear double-stranded DNA bands)

20-abx098047
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100bp Plus DNA Marker (12 linear double-stranded DNA bands)

20-abx098053
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100bp Plus DNA Marker (14 linear double-stranded DNA bands)

20-abx098054
  • EUR 360.00
  • EUR 243.60
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  • 500 ul

Universal Detachment Solution

AD002 100 ml
EUR 177.6

Universal Neutralization Buffer

NB001 100 ml
EUR 162

Universal Spring Platform

H1000-P-SP 1 PC
EUR 388.07

Universal qPCR Mixture

QPCR1000-UNIV 4X1.25ml
EUR 331.44

UNIVERSAL BEER AGAR

U21-100-10kg 10 kg
EUR 1828.8

UNIVERSAL BEER AGAR

U21-100-2kg 2kg
EUR 444

UNIVERSAL BEER AGAR

U21-100-500g 500 g
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UNIVERSAL PREENRICHMENT BROTH

U21-101-10kg 10 kg
EUR 898.8

UNIVERSAL PREENRICHMENT BROTH

U21-101-2Kg 2 Kg
EUR 242.4

UNIVERSAL PREENRICHMENT BROTH

U21-101-500g 500 g
EUR 109.2

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